Tuesday, April 30, 2013

Yahoo's Android app catches up with iOS version, gets Summly news boost

Yahoo's Android app gets Summly news search boost, catches up with iOS

Yahoo's new app has arrived on Android, packing a similar features selection to the iOS iteration that launched last week. Alongside better search language algorithms, there's the same Summly magic attempting to whittle longer news articles down to 400 characters or less. The news app will make better use of your smartphone screen too, with more attention being paid to both images and video content. Feast your eyes on Yahoo's refresh by grabbing the app at the Play store -- the link's just below.

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Via: The Verge

Source: Google Play

Source: http://www.engadget.com/2013/04/30/yahoos-android-app-update/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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TwoBadTourists | Four Fun Games That Fit In Your Travel Luggage

Before we left on our year long backpacking journey around the world, I had made some assumptions about the trip. Many assumptions. One of those was that we would play lots of games. I brought a deck of cards thinking we?d play rummy all the time. We played twice. I downloaded a chess app on our iPad thinking I?d finally learn to play. We never opened it. So how did we pass so much time when traveling on planes, buses, and trains? Well Auston slept nearly the entire time, waking to eat a snack and then passing back out. And I read a lot.

Still, we do love playing games back home and I like to think I come from a game-loving family. My mom and sister are always introducing new games to us and some of them are perfect for travelers. As we begin planning some side trips around Spain and France, it?s time to think about excellent game options for traveling light!

Let?s get more creative than a deck of cards. Everyone knows they can bring one and probably should because game options are endless. Of course there are also the games requiring no supplies at all like ?20 Questions? and ?Would You Rather?. If those suit you then great, but if you?re over the typical card and verbal games, then here are some other options to consider adding to your travel luggage for your next trip.

1. Farkle

Courtesy of elversonpuzzle.com/farkle

Courtesy of elversonpuzzle.com/farkle

This is a dice game that was introduced to us by our family when we arrived home from our round-the-world trip. It involves?a bit of luck and little strategy as you roll six dice, keeping the points you want. Then you re-roll the remaining dice while being cautious that if no more scoring dice are rolled, you lose all your points for that round. All you need is at least two players, six dice and a way of keeping score (pen/paper or phone/tablet).?Rules here.

2. Quiddler

Courtesy of boardsillyonline.com

Courtesy of boardsillyonline.com

If you?re into word games but don?t fancy traveling around with a whole Scrabble set, then Quiddler is a great option. It?s a card game where the goal is to create words with the highest point value possible beginning the first round with only three cards and working your way up to the final round with ten cards. It can be played with 1-8 players so you can pass the time solo or with some new travel friends. Rules here.

3. Bananagrams

Courtesy of banagrams.net

Courtesy of banagrams.net

Another fun word game that?s even more reminiscent of Scrabble is Bananagams, for 2-7 players. Every player works independently and simultaneously to build words from the letter tiles in a crossword format. Once a player has used up all their tiles without any misspellings or incorrect words, that player is declared the winner. Rules here.

4. Pass the Pigs

Courtesy of www.flickr.com/photos/julianhoad/1935174003

Courtesy of www.flickr.com/photos/julianhoad/1935174003

This is the only game on the list that we haven?t actually played before but it was recommended to us as fun game that?s convenient for travel as well. All you need is the two pig dice and a way of keeping score. The game is for two to ten players and like Farkle, it?s about pressing your luck. If you roll the pigs in a scoring position (the way they land is worth various points), you decided wether to take the points and end your turn or roll again and risk losing all your points. How lucky do you feel? Rules here.

There you have four great game options that won?t take up the precious remaining space in your travel luggage. Add them to your travel gear and be ready to entertain yourself because you never know when you?ll have a long, boring flight delay!

Have you ever played any of these games? What?d you think? What?s your favorite game to have for your travels? Let us know!

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Source: http://www.twobadtourists.com/2013/04/29/four-fun-games-that-fit-in-your-travel-luggage/

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Up Close On The Trail Of Indias Tigers - ArticleSnatch.com

If you're a wildlife enthusiast looking for a rewarding destination, why not head to India in search of one of the planets most majestic big cats, the Tiger? Holiday companies with a focus on wildlife can organise some excellent trips to all of Indias famous and exciting nature reserves - many of which are home to increasing populations of the once endangered animal. India is one of the few places in the world today where you can still see a Tiger in its natural habitat, and, in an effort to keep it this way, authorities have made a concerted effort to establish protected areas and national parks in which its territory is kept safe. There are very few experiences that match the excitement of seeing a wild animal in its own, natural habitat, and you cannot fail to be awed by the incredible beauty and intense grace of the Tiger. Holiday destinations for wildlife lovers do not come better than India.

Indias Finest Reserves

The majority of Indias Tiger reserves are located in Madhya Pradesh in the rural part of northern India. From Bandhavgarh, Ranthambore, Pench and Kanha, every reserve has something unique to offer the discerning wildlife enthusiast. To make the most out of your Tiger holiday it is best to spend a few days at a time in the reserves in order to get the best chance of sightings. Every day you will be taken into the jungle in small jeeps on game drive safaris; the first one leaves early in the morning and the second leaves in the afternoon, giving you the opportunity to appreciate how the jungle inhabitants behave and adapt at different times throughout the day. All game drives are accompanied by a naturalist guide, so make the most of their knowledge and expertise to really get the best from your stay in the jungle.

Accommodation in the reserves is simple but authentic, with all modern conveniences on hand. Imagine going to bed at night listening to the howling of the Indian Wild Dogs and waking in the morning to the squawking of playful monkeys; staying in the reserves gives you a real sense of being a part of the continuing circle of life that thrives here.

Your tiger holiday can be extended to include trips to some of Indias other glamorous attractions. Why not add in a day in Agra at the Taj Mahal? (Visit early in the morning to get the best photographs.) Or perhaps spend a few days in Delhi exploring the old town with its vibrant markets, busy streets and fascinating food stalls. Wherever you go in India you will be bombarded with a feast for the senses. This eclectic country has so much to offer in every aspect, and a visit here will be one that remains with you always.

Marissa Ellis-Snow is a freelance nature writer. If youre looking for a Tiger holiday, Naturetrek specialises in expert-led natural history and wildlife tours worldwide. Naturetrek brings over 25 years of experience to to wildlife tours to some of the most spectacular regions on Earth.

Source: http://www.articlesnatch.com/Article/Up-Close-On-The-Trail-Of-India---s-Tigers/4580702

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Monday, April 29, 2013

Mother in UK forced 14-year-old to get pregnant

LONDON (AP) ? A woman desperate for another child forced her 14-year-old daughter to get pregnant using syringes of donor sperm, a British judge said.

In a ruling reported for the first time Monday, High Court judge Peter Jackson said the mother had behaved in "a wicked and selfish way" that almost defied belief.

The judge said the woman, an American divorcee living in Britain with three adopted children, hatched the plan after she was prevented from adopting a fourth.

The scheme involved getting her oldest daughter to inseminate herself with syringes of sperm purchased over the Internet from a Denmark-based company, Cryos International.

Jackson said the daughter, identified only as A, "became pregnant at the mother's request, using donor sperm bought by the mother, with the purpose of providing a fourth child for the mother to bring up as her own."

In his ruling, the judge quoted the teenager as saying said she was shocked by the suggestion, but thought, "If I do this ... maybe she will love me more."

"My mum is a very determined person and she does her best not to let anything get in her way if she wants it," the teenager added.

The judge said the mother also made the teenager use douches of vinegar or lemon and lime juice in hopes of increasing her chances of having a girl.

The judge said it was likely but not certain that the daughter soon became pregnant and suffered a miscarriage. After six more attempts with the donor sperm, she gave birth to a baby boy in July 2011, when she was 17.

But midwives at the hospital became alarmed by the odd behavior of A's mother. Her daughter wanted to breastfeed the baby, but her mother said: "We don't want any of that attachment thing."

The hospital alerted the authorities, and the children were taken into foster care. The mother is now serving a five-year jail term for child cruelty.

Details of the case were heard during proceedings at the family division of the High Court over the children's future last year. They were reported for the first time Monday after several British media organizations, including the publisher of The Guardian newspaper, challenged reporting restrictions.

A court order bars identifying the family members in order to protect the children.

Source: http://news.yahoo.com/mother-uk-forced-14-old-pregnant-131603990.html

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Breyer has shoulder surgery after bike accident

In this photo taken Jan. 24, 2013, file photo U.S. Supreme Court Justice Stephen Breyer reacts during a lecture at Boston University School of Law in Boston. Breyer is in a Washington hospital after shoulder replacement surgery following a bicycle accident injury to his right shoulder Friday, April 26, 2013. Court spokeswoman Kathy Arberg says the 74-year-old Breyer is expected to make a full recovery following the operation Saturday. Previously he broke his collarbone in an accident in 2011 and sustained broken ribs and a punctured lung in a bicycle mishap in 1993, before he joined the court. (AP Photo/Elise Amendola)

In this photo taken Jan. 24, 2013, file photo U.S. Supreme Court Justice Stephen Breyer reacts during a lecture at Boston University School of Law in Boston. Breyer is in a Washington hospital after shoulder replacement surgery following a bicycle accident injury to his right shoulder Friday, April 26, 2013. Court spokeswoman Kathy Arberg says the 74-year-old Breyer is expected to make a full recovery following the operation Saturday. Previously he broke his collarbone in an accident in 2011 and sustained broken ribs and a punctured lung in a bicycle mishap in 1993, before he joined the court. (AP Photo/Elise Amendola)

(AP) ? Supreme Court Justice Stephen Breyer is in a Washington hospital after shoulder replacement surgery following a bicycle accident.

Court spokeswoman Kathy Arberg says the 74-year-old Breyer is expected to make a full recovery following the operation Saturday.

Breyer injured his right shoulder in a fall Friday near the Korean War Veterans Memorial.

The justice previously broke his collarbone in an accident in 2011 and sustained broken ribs and a punctured lung in a bicycle mishap in 1993, before he joined the court.

Breyer was appointed to the court in 1994 by President William Clinton.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-04-27-Justice%20Breyer-Surgery/id-68f92c8dc1ea4b5ebf12c83ef39f61aa

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Sunday, April 28, 2013

Chris Pine and Dominique Piek: It's Over!

Source: http://www.thehollywoodgossip.com/2013/04/chris-pine-and-dominique-piek-its-over/

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Owner arrested as Bangladesh building toll reaches 372

By Serajul Quadir and Ruma Paul

DHAKA (Reuters) - Hope for survivors under the rubble of a building that collapsed outside the capital of Bangladesh faded on Sunday, and with more than 900 people still counted as missing fears grew that the death toll could rise far beyond the latest figure of 363.

Four people were pulled alive from the wreckage of the Rana Plaza, which housed several factories making low-cost garments for Western retailers, four days after the country's worst-ever industrial accident.

Rescuers worked frantically through the morning to release several others who fire service Deputy Director Mizanur Rahman said were trapped under the mound of broken concrete and metal.

"The chances of finding people alive are dimming, so we have to step up our rescue operation to save any valuable life we can," said Major General Chowdhury Hassan Sohrawardi, coordinator of the operation at the site.

About 2,500 people have been rescued from the remains of the building in the commercial suburb of Savar, about 30 km (20 miles) from the capital, Dhaka.

Officials said the eight-storey tower had been built on spongy ground without the correct permits, and more than 3,000 workers - mainly young women - had been sent in on Wednesday morning despite warnings that it was structurally unsafe.

Police said one factory owner gave himself up following the detention of two plant bosses and two engineers the day before.

The owner of the building, identified by police as Mohammed Sohel Rana, a leader of the ruling Awami League's youth front, was still on the run. Airport and border authorities have been alerted to prevent Rana from fleeing the country.

Police have also detained several of his relatives to compel him to surrender and to find out where he might be. Local news reports said his mother, who was not being held, died of a heart attack on Saturday evening.

Anger at the negligence sparked days of protests and clashes, with police using tear gas, water cannons and rubber bullets to quell demonstrators who set cars ablaze. On Sunday, however, the roads were quiet.

The main opposition, joining forces with an alliance of leftist parties which is part of the ruling coalition, called for a national strike on May 2 in protest over the incident.

BUILT ON A FILLED-IN POND

Wednesday's collapse was the third major industrial incident in five months in Bangladesh, the second-largest exporter of garments in the world behind China. In November, a fire at the Tazreen Fashion factory in a suburb of Dhaka killed 112 people.

Such incidents have raised serious questions about worker safety and low wages, and could taint the reputation of the poor South Asian country, which relies on garments for 80 percent of its exports. The industry employs about 3.6 million people, most of them women, some of whom earn as little as $38 a month.

Emdadul Islam, chief engineer of the state-run Capital Development Authority (CDA), said on Saturday that the owner of the building had not received the proper construction consent, obtaining a permit for a five-storey building from the local municipality, which did not have the authority to grant it.

"Only CDA can give such approval," he said. "We are trying to get the original design from the municipality, but since the concerned official is in hiding we cannot get it readily."

Furthermore, another three storeys had been added illegally, he said. "Savar is not an industrial zone, and for that reason no factory can be housed in Rana Plaza," Islam told Reuters.

Islam said the building had been erected on the site of a pond filled in with sand and earth, weakening the foundations.

Since the disaster, the Bangladesh Garment Manufacturers and Exporters Association (BGMEA) has asked factory owners to produce building designs by July in a bid to improve safety.

(Writing by John Chalmers)

Source: http://news.yahoo.com/hope-survivors-fades-bangladesh-building-toll-reaches-363-082504472.html

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Researcher studies hormone levels and sexual motivation among young women

Friday, April 26, 2013

Feeling frisky? If so, chances are greater your estrogen level ?? and, perhaps, fertility ?? are hitting their monthly peak. If not, you're more likely experiencing a profusion of desire-deadening progesterone, and the less fertile time in your cycle. Oh, the power of hormones.

Researchers have long suspected a correlation between hormone levels and libido, but now scientists at UC Santa Barbara, led by James Roney, a professor in the Department of Psychological and Brain Sciences, have actually demonstrated hormonal predictors for sexual desire. Their findings appear in the current issue of the journal Hormones and Behavior.

"We found two hormonal signals that had opposite effects on sexual motivation," said Roney, the article's lead author. "Estrogen was having a positive effect, but with a two-day lag. Progesterone was having a persistent negative effect, both for current day, day before, and two days earlier." When hormone levels and sexual desire were factored against the menstrual cycles of test subjects ?? in this case, undergraduate students ?? the researchers saw a measurable increase in progesterone levels at the same time the subjects noted decreases in sexual motivation. Progesterone, the researchers say, is mediating this drop in desire from the fertile window to the luteal phase ?? the second half of the menstrual cycle.

"Progesterone acting as a potential stop signal within cycles is a novel finding in humans," noted Roney. "We know in rhesus monkeys there is a strong negative correlation with progesterone and a positive correlation with estrogen. The patterns are actually comparable to what you see in non-human primates, but hadn't been shown in humans."

The researchers' findings have potential implications on the treatment of low sexual desire and how hormone replacement trials are done. "We're not controlling hormones the way they do in the hormone replacement literature, so, in a sense, that literature is more directly applicable in terms of medical applications," said Roney. "But in the long run, it would be good to have a model of the combination of signals that operates in the natural cycle. The way hormone replacement trials are done now, there's no model of the natural signals, so they're sort of random ?? let's give estrogen, let's give testosterone, let's combine them this way or that way."

Roney noted that his findings don't present a full model, and he'd like to replicate his results with women of different age groups. "Undergraduates might be unique for a lot of reasons," he said. "Their hormone levels tend to be a bit different from those of women even just a little bit older. And married women in their 30's are likely to be more consistently sexually active, and that might change the patterns in some ways. They also tend to have higher hormone secretion and more regular cycles than younger women," he said

Eventually, Roney continued, the goal would be to have a better model of the signals in a natural cycle that might then inform medical research.

Another interesting finding, according to Roney, was the impact ?? or lack thereof ?? of testosterone on the women's sexual motivation. "There's a common belief in the medical literature that testosterone is the main regulator of women's libido," he explained. "Doctors tend to believe that, though the evidence isn't that strong in humans. In the natural cycles, we weren't finding effects of testosterone. It wasn't significantly predicting outcomes."

Roney doesn't deny that testosterone does seem to have a positive effect in hormone replacement therapy, but suggests the effects may be pharmacological. "Testosterone has those effects if you inject it externally in women who are menopausal, and there are a lot of reasons that might be the case," he said. "For example, testosterone can be converted to estrogen through a particular enzyme. If you inject menopausal women with testosterone, it might be acting as a device that's delivering estrogen to the target cells. So the fact that it works doesn't necessarily mean it's an important signal in the natural cycle."

###

University of California - Santa Barbara: http://www.ucsb.edu

Thanks to University of California - Santa Barbara for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 75 time(s).

Source: http://www.labspaces.net/127964/Researcher_studies_hormone_levels_and_sexual_motivation_among_young_women

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Saturday, April 27, 2013

Weekend cooking ? fried squash blossoms (Americablog)

Share With Friends: Share on FacebookTweet ThisPost to Google-BuzzSend on GmailPost to Linked-InSubscribe to This Feed | Rss To Twitter | Politics - Top Stories News, RSS and RSS Feed via Feedzilla.

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Dot Earth Blog: A Cool But Splendid Spring in the Northeast

I had a rare moment to walk in the woods and breath the unusually cool spring air this morning and noted, thanks to my naturalist spouse, Lisa Mechaley, that the Canada mayflower (a.k.a. false lily of the valley) was bursting forth.

What?s blooming near you this spring? Send links to your photos on Instagram, Twitpic, Flickr, Facebook or other online venues and I?ll add them.

As you can see in the National Climatic Data Center records for March, a cool (or hot) spring in one place and year has little meaning if your concerns are with long-term climate change, so let?s not get into that in the comments here, please.

Source: http://dotearth.blogs.nytimes.com/2013/04/26/a-cool-but-splendid-spring-in-the-northeast/?partner=rss&emc=rss

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Friday, April 26, 2013

38 die in psychiatric hospital fire near Moscow

MOSCOW (AP) ? At least 38 people died in a fire in a psychiatric hospital outside Moscow late Thursday night.

Police said the fire, which broke out at about 2 a.m. local time (6 p.m. Eastern, 2200 GMT) in the one-story hospital in the Ramenskoye settlement, was caused by a short circuit, the RIA Novosti reported on Friday.

Officials from the Russian Investigative Committee later said they are looking at poor fire regulations and short circuit as possible causes.

By early Friday morning, investigators listed 38 people ? 36 patients and two doctors ? as dead. Only three nurses managed to escape. The emergency services also posted a list of the patients indicating they ranged in age from 20 to 76.

Health Ministry officials said that hospital housed patients with severe mental disorders. Vadim Belovoshin from the emergency situations ministry official told the Itar-TASS news agency that the windows in the hospital were barred but said there were two fire escapes.

Belovoshin also said that it took fire fighters an hour to get to the hospital following an emergency call because a local ferry across the river was closed and the fire fighters had to make a detour.

Deadly fires are common in Russia because of wide-spread violations of fire safety rules.

Source: http://news.yahoo.com/38-die-mental-hospital-fire-outside-moscow-051615611.html

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Key cellular organelle involved in gene silencing identified

Apr. 25, 2013 ? RNA molecules, made from DNA, are best known for their role in protein production. MicroRNAs (miRNAs), however, are short (~22) nucleotide RNA sequences found in plants and animals that do not encode proteins but act in gene regulation and, in the process, impact almost all biological processes -- from development to physiology to stress response.

Present in almost in every cell, microRNAs are known to target tens to hundreds of genes each and to be able to repress, or "silence," their expression. What is less well understood is how exactly miRNAs repress target gene expression.

Now a team of scientists led by geneticists at the University of California, Riverside has conducted a study on plants (Arabidopsis) that shows that the site of action of the repression of target gene expression occurs on the endoplasmic reticulum (ER), a cellular organelle that is an interconnected network of membranes -- essentially, flattened sacs and branching tubules -- that extends like a flat balloon throughout the cytoplasm in plant and animal cells.

"Our study is the first to demonstrate that the ER is where miRNA-mediated translation repression occurs," said lead researcher Xuemei Chen, a professor of plant cell and molecular biology and a Howard Hughes Medical Institute-Gordon and Betty Moore Foundation Investigator. "To understand how microRNAs repress target gene expression, we first need to know where microRNAs act in the cell. Until now no one knew that membranes are essential for microRNA activity. Our work shows that an integral membrane protein, AMP1, is required for the miRNA-mediated target gene repression to be successful. As AMP1 has counterparts in animals, our findings in plants could have broader implications."

Study results appear today in the journal Cell.

Simply put, DNA makes RNA, and then RNA makes proteins. Specifically, RNA encodes genetic information that can be "translated" into the amino acid sequence of proteins. But noncoding RNAs -- RNAs that do not encode proteins -- are increasingly found to act in numerous biological processes. MicroRNAs are a class of noncoding RNAs whose main function is to downregulate gene expression.

Research on miRNAs has increased tremendously since they were first identified about 20 years ago. In the case of diseases, if some genes are up- or down-regulated, miRNAs can be used to change the expression of these genes to fight the diseases, thus showing therapeutic potential.

MicroRNAs are known to regulate target genes by two major modes of action: they either destabilize the target RNAs, leading to their degradation, or they do not impact the stability of the target RNAs, but simply prevent them from being translated into proteins -- a process known as translation inhibition. The end result of translation inhibition is that the genes do not get expressed. Just how miRNAs cause translational inhibition of their target genes is not well understood.

"We were surprised that the ER is required for the translational inhibition activity of miRNAs," Chen said. "This new knowledge will expedite our understanding of the mechanism of gene silencing. Basically, now we know where to look: the ER. We also suspect it is the rough ER portions that are involved."

Chen explained that the ER has two types: rough and smooth. Rough ER, which synthesizes and packages proteins, looks bumpy; smooth ER, which acts in lipid synthesis and protein secretion, resembles tubes. The ER protein AMP1, she said, is anchored in the rough ER.

"My lab has been conducting research on AMP1 for many years," she said. "And it's this protein that drew our attention to the ER. First, we realized that AMP1 is involved in miRNA-mediated translational inhibition. Then, since we already knew that AMP1 is localized in the rough ER, we shifted our focus to this organelle."

Next, her lab will attempt to crack the mechanism of miRNA-mediated translational inhibition. They will investigate, too, how miRNAs are recruited to the ER.

Chen was joined in the study by Shengben Li (first author of the research paper), Lin Liu, Xigang Liu, Yu Yu, Lijuan Ji and Natasha Raikhel at UC Riverside; Xiaohong Zhuang and Liwen Jiang at the Chinese University of Hong Kong; Xia Cui and Xiaofeng Cao at the Chinese Avademy of Sciences, Beijing; Zhiqiang Pan at the University of Mississippi; Beixin Mo at Shenzhen University, China; and Fuchun Zhang at Xinjiang University, China.

The study was supported by grants to Chen from the National Institutes of Health, the National Science Foundation, and the Howard Hughes Medical Institute and Gordon and Betty Moore Foundation.

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The above story is reprinted from materials provided by University of California - Riverside. The original article was written by Iqbal Pittalwala.

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Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/hP4uiZtvpTo/130425132656.htm

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Thanks to rare alpine bacteria, researchers identify one of alcohol's key gateways to the brain

Thanks to rare alpine bacteria, researchers identify one of alcohol's key gateways to the brain

Friday, April 26, 2013

Thanks to a rare bacteria that grows only on rocks in the Swiss Alps, researchers at The University of Texas at Austin and the Pasteur Institute in France have been the first to identify how alcohol might affect key brain proteins.

It's a major step on the road to eventually developing drugs that could disrupt the interaction between alcohol and the brain.

"Now that we've identified this key brain protein and understand its structure, it's possible to imagine developing a drug that could block the binding site," said Adron Harris, professor of biology and director of the Waggoner Center for Alcohol and Addiction at The University of Texas at Austin.

Harris and his former postdoctoral fellow Rebecca Howard, now an assistant professor at Skidmore College, are co-authors on the paper that was recently published in Nature Communications. It describes the structure of the brain protein, called a ligand-gated ion channel, that is a key enabler of many of the primary physiological and behavioral effects of alcohol.

Harris said that for some time there has been suggestive evidence that these ion channels are important binding sites for alcohol. Researchers couldn't prove it, however, because they couldn't crystallize the brain protein well enough, and therefore couldn't use X-ray crystallography to determine the structure of the protein with and without alcohol present.

The advance came when Marc Delarue and his colleagues at the Pasteur Institute sequenced the genome of cyanobacteria Gloeobacter violaceus. They noted a protein sequence on the bacteria that is remarkably similar to the sequence of a group of ligand-gated ion channels in the human brain. They were able to crystallize this protein. Harris saw the results and immediately got in touch.

"This is something you never would have found with any sort of logical approach," he said. "You never would have guessed that this obscure bacterium would have something that looks like a brain protein in it. But the institute, because of Pasteur's fascination with bacteria, has this huge collection of obscure bacteria, and over the last few years they've been sequencing the genomes, keeping an eye out for interesting properties."

Harris and Howard asked their French colleagues to collaborate, got the cyanobacteria, changed one amino acid to make it sensitive to alcohol, and then crystallized both the original bacteria and the mutated one. They compared the two to see whether they could identify where the alcohol bound to the mutant. With further tests they confirmed that it was a meaningful site.

"Everything validated that the cavity in which the alcohol bound is important," said Harris. "It doesn't account for all the things that alcohol does, but it appears to be important for a lot of them, including some of the 'rewarding' effects and some of the negative, aversive effects."

Going forward, Harris and his lab plan to use mice to observe how changes to the key protein affect behavior when the mice consume alcohol.

They're also hoping to identify other important proteins from this family of ligand-gated ion channels. In the long term, he hopes to be involved in developing drugs that act on these proteins in ways that help people diminish or cease their drinking.

"So why do some people drink moderately and some excessively?" he said. "One reason lies in that the balance between the rewarding and the aversive effects, and that balance is different for different people, and it can change within an individual depending on their drinking patterns. Some of those effects are determined by the interactions of alcohol and these channels, so the hope is that we can alter the balance. Maybe we can diminish the reward or increase the aversive effects."

###

University of Texas at Austin: http://www.utexas.edu

Thanks to University of Texas at Austin for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

This press release has been viewed 47 time(s).

Source: http://www.labspaces.net/127966/Thanks_to_rare_alpine_bacteria__researchers_identify_one_of_alcohol_s_key_gateways_to_the_brain

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Is the Gilbert Education Association gone? ? Gilbert / Higley Public ...

By admin, on April 24th, 2013

?Union? is a word that most GEA leadership prefers to avoid, and it appears to be a concept that GPS school board member Daryl Colvin along with board President Staci Burk and board?Clerk?Julie Smith feel GPS?are better off without.

In a 3-2 vote on a substitute motion?(board members Lily Tram and Jill Humphreys dissenting) the GPS school board has essentially nullified the Memorandum of Understanding (MOU) and moved the bulk of the policies and procedures referenced therein to official district policy.? Mr. Colvin explained that GPS district policies already referring to the MOU for additional reference can now reference official district policy and apply?to 100% of the staff rather than just 33% of staff that are GEA members.? In addition, the first two articles of the MOU which contain language that establishes the nature of the association have been removed from the new policy.? The question now becomes, what of the GEA?

Just prior to this unprecedented action, Mr. Jeff Smith spoke during public comment giving his?opinion against the measure to renew the MOU and citing references of high-ranking national teacher?s union representatives painting unions in unfavorable light.?

Ms. Burk suggested that current committees involving the MOU such as the IBBT (Interest-Based Bargaining Team) be transitioned as a sub-committee to the policy committee to finalize language and iron out any wrinkles going forward.

Board member Mrs. Jill Humphreys went to extra lengths after the vote was taken to emotinally express her reason for dissention by sharing concerns that moving so much into policy so quickly was ill advised and felt that such actions diminished the voice of the teachers whom were represented by the GEA.? Board President Ms. Staci Burk explained that in her opinion the action actually strengthened the teacher?s representative position by including them in the policy committee, an area such representation has not been given before in such a way as this.

As the dust settles, future meetings will be of great interest to many concerned individuals as this particular shift in policy and direction continues to take shape.? When pressed by board member Lily Tram if the intention was to do away with the GEA, President Burk indicated that the school board doesn?t have the authority to disband the GEA.? Yet by all appearances, it would appear that while the GEA is still free to remain organized, the logistics of their organization will certainly need to be reviewed internally and most if not all ties to GPS appear to be severed pending further policy revision.

Source: http://gilbertschools.info/2013/04/24/is-the-gilbert-education-association-gone/

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Thursday, April 25, 2013

Dems, GOP talk up deficit reduction, but don't act

(AP) ? Liberals' loud objections to White House proposals for slowing the growth of huge social programs make it clear that neither political party puts a high priority on reducing the deficit, despite much talk to the contrary.

For years, House Republicans have adamantly refused to raise income taxes, even though U.S. taxes are historically low, and the Bush-era tax cuts were a major cause of the current deficit.

And now, top Democrats are staunchly opposing changes to Medicare and Social Security benefits, despite studies showing the programs' financial paths are unsustainable.

Unless something gives, it's hard to see what will produce the significant compromises needed to tame the federal debt, which is nearing $17 trillion.

"There's not much of an appetite for deficit reduction," said Bob Bixby of the Concord Coalition, which pushes for "responsible fiscal policy."

There might be a few small steps this year, he said, when the government again needs to raise its borrowing limit. But a "grand bargain" involving significant spending cuts and revenue increases seems unlikely, Bixby said.

He added, "It's a little depressing to hear the reactions to the president's budget, from both sides."

There was nothing surprising about Republican denunciations of Obama's proposed tax increases, which he wants to combine with spending cuts to reduce the deficit.

The newer wrinkle was the left's sharp criticism of his proposals to slow the growth in Medicare and Social Security benefits, provided Republicans agree to new revenues. Obama has offered Republicans such a deal before. But this month's budget proposal gave it a new imprimatur.

The group MoveOn.org said Wednesday that supporters "who are outraged at President Obama's proposal to cut Social Security benefits will protest and deliver petitions" this week.

Sen. Bernie Sanders, a liberal independent from Vermont, is leading a similar petition drive, opposing "any benefit cuts to Social Security, Medicare or Medicaid." The deficit, his letter says, "was primarily caused during the Bush years by two unpaid-for wars, huge tax breaks for the rich and a prescription drug program" for Medicare, funded through borrowing. He suggests that higher taxes on the wealthy are the fairest way to tackle the deficit.

Democrats cite several reasons to raise taxes on high-income households. Obama campaigned for such tax increases in 2008 and 2012 but accomplished them only partially with the "fiscal cliff" resolution of Jan. 1.

Major tax cuts in 2001 and 2003 played big roles in turning a federal budget surplus into soaring deficits, according to research by the Congressional Budget Office and others. And by many measures, the U.S. tax burden in near historic lows.

Households earning roughly the national median income paid, on average, 11.1 percent of their income in total federal taxes in 2009, the most recent year for such data. That's the lowest level in more than 30 years, the CBO says.

Nonetheless, House Republicans have placed their highest priority on refusing to raise income tax rates, effectively ranking it above all other goals.

"The president got his tax hikes on Jan. 1," House Speaker John Boehner, R-Ohio, is fond of saying. It's a reference to the $620 billion in new revenues, over 10 years, that Republicans were unable to stop because of the "fiscal cliff" law, resolved on New Year's Day.

If it's easy to make a case for higher revenues, the same is true for slowing the growth of Social Security and Medicare benefits. For decades, studies have warned of approaching trouble in these popular but costly programs, as health care costs rise and baby boomers begin to retire.

"Both Medicare and Social Security cannot sustain projected long-run program costs under currently scheduled financing, and legislative modifications are necessary to avoid disruptive consequences for beneficiaries and taxpayers," the Social Security Administration says, summarizing findings by the two programs' trustees.

"The early detection light has been going on for a while, and there has been a failure to act," Social Security trustee Charles P. Blahous recently told a House panel. If lawmakers are to preserve the programs for future retirees, he said, they will have to accept much more "political pain" than officials endured during a 1983 overhaul that included "several extremely controversial measures."

Obama has proposed an often-discussed step, which deals with government accounting in general, not just entitlement programs. If Congress agrees to higher tax revenues, the president said, he would back a slower growth calculation for cost-of-living increases for Social Security benefits, plus higher Medicare premiums for higher-income seniors.

Interest groups have criticized both ideas. AARP calls the slower cost-of-living formula a "harmful change," and urges seniors to oppose it.

American voters can largely blame themselves when Congress is more talk than action on deficit reduction. Americans routinely say they want a smaller federal debt, but not at the cost of programs they hold dear ? including Social Security and Medicare.

A CBS News poll in March found that most Americans want to cut spending and raise taxes to reduce the deficit. But 4 in 5 oppose cuts to Social Security or Medicare. And two-thirds are unwilling to have their own taxes raised in the name of deficit reduction.

When Pew Research asked which was more important ? reducing the national debt or keeping Social Security and Medicare benefits as they are now ? the public sided with safeguarding the benefits programs, 53 percent to 36 percent.

The deficit-spending partisanship continued Wednesday. On a party-line vote, House Ways and Means Committee Republicans passed a bill to protect Social Security recipients and investors in Treasury bonds if the government hits its borrowing limit and can't pay all its bills later this year. Democrats say if the federal government starts reneging on any obligations ? even if it pays bondholders ? financial markets will lose faith and the economy will tank.

Some Democrats fear a lose-lose situation if they support Obama's proposals. First, they could be attacked from the left for tweaking the programs that many Democrats see as their party's greatest legacy. And second, Republicans might accuse them of "raiding Medicare" in next year's congressional elections. That battle cry proved effective in 2010 after Obama's health care overhaul bill was passed.

Democrats call such tactics shamelessly hypocritical. Republicans, they note, have long called for reining in entitlement spending.

Boehner rebuked a top GOP campaign figure for hinting at a renewal of the "raiding Medicare" attacks. But Reince Priebus, the national Republican Party chairman, seemed eager to revive the question of whether Democratic trims to Medicare's costs amount to an unfair cut in benefits.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/89ae8247abe8493fae24405546e9a1aa/Article_2013-04-25-Budget%20Impasse/id-1c2bbd5f0fa8425582882f41f673ffeb

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Catch Notes for iPhone and iPad review: Organize all your ideas, notes, and reminders

Catch Notes for iPhone and iPad review: Organize all your ideas, notes, and reminders

If you're looking for a fresh take on a get things done app, Catch Notes for iPhone and iPad does just that. Not only does Catch Notes combine reminders, notes, ideas, and checklists into one app, it does it with a great interface while also supporting many common task types. Whether you want to upload photos, take free hand notes, or be reminded to do something, Catch Notes can do it all within one singular app.

Catch Notes starts by allowing you to create spaces for better organizing your data. By default, you can create up to five spaces for free. After that, you can buy additional spaces as an in-app purchase. For most users, five spaces will be plenty to at least get started. These areas can be used in any manner you'd like. For instance, you can have one space for work and another for home. You can also choose to re-order them by simply dragging them in the main list in any order you'd like. If you consistently work on several projects at one time that you'd like to keep separate, you may have a need for more spaces.

Once you have set up your spaces and organized Catch notes the way you'd like, you can start adding notes and other types of content into any space you'd like. Along the bottom of Catch Notes, tap on the "+" sign to start creating and adding content. Supported media types include standard text notes, reminders (with notifications), photos, audio notes, and checklists. You can create as many of these items as you'd like within any space. For people attempting to organize many projects, you can create several checklists within a space for as many projects as you'd like. Catch Notes also supports hashtags which makes searching for notes easier. Just tag them however you'd like. Catch Notes will start aggregating tags you use frequently as you type them for quicker tagging.

You can share spaces with other Catch Notes users as well. This way you can collaborate on projects or group tasks easier and without having to email or compare notes. If you do need to share something with someone that isn't using Catch Notes, you can always do so by emailing any note you have stored. You can also attach photos to existing notes by either snapping a new picture or using one that already exists in your camera roll.

The good

  • Easy to set up and start using in a matter of seconds
  • The initial five space allotment will be plenty for most users
  • Notifications work well eliminate the need for a reminders app on top of a task management app
  • Great interface that's not only clean, but has a sensible workflow
  • Native sync at no additional cost, which is great if you want to use both the iPhone and iPad version

The bad

  • No way to change notification tone
  • It'd be nice to see more share options, such as to other apps or via other delivery methods other than email

The bottom line

Catch Notes is very reminiscent Evernote with the added ability for reminders. The only down side is that Catch Notes doesn't have a Mac counterpart at this time. For most users that have a need to manage multiple projects or notes, they'll most likely want the ability from their Mac as well. If that sounds like you, a productivity suite such as Things is probably a better option.

If you aren't a Mac user or don't care about having a desktop client, Catch Notes makes a great alternative to some of the more expensive get things done apps out there. Considering you can get started at no cost to you, there's nothing to lose by at least giving it a try.

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/v186Sif33iI/story01.htm

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Earthquake Hits Afghanistan (Voice Of America)

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Minaret of landmark mosque in Syria destroyed

This journalism image provided by Aleppo Media Center AMC which has been authenticated based on its contents and other AP reporting, shows the damaged famed 12th century Umayyad mosque without the minaret, background right corner, which was destroyed by the shelling, in the northern city of Aleppo, Syria, Wednesday April 24, 2013. The minaret of a famed 12th century Sunni mosque in the northern Syrian city of Aleppo was destroyed Wednesday, leaving the once-soaring stone tower a pile of rubble and twisted metal scattered in the tiled courtyard. President Bashar Assad's regime and anti-government activists traded blame for the attack against the Umayyad mosque, which occurred in the heart Aleppo's walled Old City, a UNESCO World Heritage site. It was the second time in just over a week that a historic Sunni mosque in Syria has been seriously damaged. (AP Photo/Aleppo Media Center, AMC)

This journalism image provided by Aleppo Media Center AMC which has been authenticated based on its contents and other AP reporting, shows the damaged famed 12th century Umayyad mosque without the minaret, background right corner, which was destroyed by the shelling, in the northern city of Aleppo, Syria, Wednesday April 24, 2013. The minaret of a famed 12th century Sunni mosque in the northern Syrian city of Aleppo was destroyed Wednesday, leaving the once-soaring stone tower a pile of rubble and twisted metal scattered in the tiled courtyard. President Bashar Assad's regime and anti-government activists traded blame for the attack against the Umayyad mosque, which occurred in the heart Aleppo's walled Old City, a UNESCO World Heritage site. It was the second time in just over a week that a historic Sunni mosque in Syria has been seriously damaged. (AP Photo/Aleppo Media Center, AMC)

COMBO - This combination of two citizen journalist images provided by Aleppo Media Center AMC which has been authenticated based on its contents and other AP reporting, shows at left: the damaged famed 12th century Umayyad mosque without the minaret, background right corner, which was destroyed by the shelling, in the northern city of Aleppo, Syria, Wednesday April 24, 2013; and at right, an undated view of the mosque with is minaret still intact. The minaret of a famed 12th century Sunni mosque in the northern Syrian city of Aleppo was destroyed Wednesday, April; 24, 2013, leaving the once-soaring stone tower a pile of rubble and twisted metal scattered in the tiled courtyard. President Bashar Assad's regime and anti-government activists traded blame for the attack against the Umayyad mosque, which occurred in the heart Aleppo's walled Old City, a UNESCO World Heritage site. It was the second time in just over a week that a historic Sunni mosque in Syria has been seriously damaged. (AP Photo/Aleppo Media Center, AMC)

In this image taken from video obtained from Aleppo Media Center AMC, which has been authenticated based on its contents and other AP reporting, shows the damaged famed 12th century Umayyad mosque, background, which was destroyed by shelling, in the northern city of Aleppo, Syria, Wednesday, April 24, 2013. The minaret of a famed 12th century Sunni mosque in the northern Syrian city of Aleppo was destroyed Wednesday, leaving the once-soaring stone tower a pile of rubble and twisted metal scattered in the tiled courtyard. President Bashar Assad's regime and anti-government activists traded blame for the attack against the Umayyad mosque, which occurred in the heart Aleppo's walled Old City, a UNESCO World Heritage site. It was the second time in just over a week that a historic Sunni mosque in Syria has been seriously damaged. (AP Photo/Aleppo Media Center, AMC)

Map locates Aleppo, Syria, where the minaret of a 12th century mosque was destroyed

This undated citizen journalism image provided by Aleppo Media Center AMC which has been authenticated based on its contents and other AP reporting, shows the minaret of a famed 12th century Umayyad mosque before it was destroyed by the shelling, in the northern city of Aleppo, Syria. The minaret of a famed 12th century Sunni mosque in the northern Syrian city of Aleppo was destroyed Wednesday, April; 24, 2013, leaving the once-soaring stone tower a pile of rubble and twisted metal scattered in the tiled courtyard. President Bashar Assad's regime and anti-government activists traded blame for the attack against the Umayyad mosque, which occurred in the heart Aleppo's walled Old City, a UNESCO World Heritage site. It was the second time in just over a week that a historic Sunni mosque in Syria has been seriously damaged. (AP Photo/Aleppo Media Center, AMC)

BEIRUT (AP) ? The minaret of a landmark 12th century mosque in the northern Syrian city of Aleppo was destroyed Wednesday, leaving the once-soaring stone tower a pile of rubble and twisted metal scattered in the tiled courtyard.

President Bashar Assad's regime and anti-government activists traded blame for the destruction to the Umayyad Mosque, which occurred in the heart Aleppo's walled Old City, a UNESCO World Heritage site.

It was the second time in just over a week that a historic Sunni mosque in Syria has been seriously damaged. Mosques served as a launching pad for anti-government protests in the early days of the country's 2-year-old uprising, and many have been targeted.

Syrian's state news agency SANA said rebels from the al-Qaida-linked Jabhat al-Nusra group blew it up, while Aleppo-based activist Mohammed al-Khatib said a Syrian army tank fired a shell that "totally destroyed" the minaret.

The mosque fell into rebel hands earlier this year after heavy fighting that damaged the historic compound. The area around it, however, remains contested. Syrian troops are about 200 meters (yards) away.

An amateur video posted online by the anti-government Aleppo Media Center activist group showed the mosque's archways, charred from earlier fighting, and a pile of rubble where the minaret used to be.

Standing inside the mosque's courtyard, a man who appears to be a rebel fighter says regime forces recently fired seven shells at the minaret but failed to knock it down. He said that on Wednesday the tank rounds struck their target.

"We were standing here today and suddenly shells started hitting the minaret," the man says. "They (the army) then tried to storm the mosque but we pushed them back."

The video appeared genuine and corresponded to other Associated Press reporting of the events depicted.

The destruction in Aleppo follows a similar incident in the southern city of Daraa, where the minaret of the historic Omari Mosque was destroyed more than a week ago. The Daraa mosque was built during the Islamic conquest of Syria in the days of Caliph Omar ibn al-Khattab in the seventh century.

In that instance as well, the opposition and regime blamed each other for the damage. SANA also accused Jabhat al-Nusra of positioning cameras around the area to record the event in that case.

Syria's civil war, with the use of everything from small arms to artillery and warplanes, poses a grave threat to the country's rich cultural heritage.

Last year, the medieval market in Aleppo, which is located near the Umayyad Mosque, was gutted by fire sparked by fighting last year.

Both rebels and regime forces have turned some of Syria's significant historic sites into bases, including citadels and Turkish bath houses, while thieves have stolen artifacts from museums.

Five of Syria's six World Heritage sites have been damaged in the fighting, according to UNESCO, the U.N.'s cultural agency. Looters have broken into one of the world's best-preserved Crusader castles, Crac des Chevaliers, and ruins in the ancient city of Palmyra have been damaged.

The damage is just part of the wider devastation caused by the country's crisis, which began more than two years ago with largely peaceful protests but morphed into a civil war as the opposition took up arms in the face of a withering government crackdown. The fighting has exacted a huge toll on the country, killing more than 70,000 people, laying waste to cities, towns and villages and forcing more than a million people to flee their homes and seek refuge abroad.

Aleppo, the country's largest city, and Damascus are two of the key fronts in the conflict, which pits the an Assad regime dominated by the president's Alawite sect, an offshoot of Shiite Islam, and a rebel movement drawn primarily from Syria's Sunni Muslim majority.

Aleppo has been carved into rebel- and regime-held zones, while Damascus remains firmly in government hands, although the rebels have established a foothold in the suburbs and hope to use their enclaves there to eventually push into the city itself.

On Wednesday, two mortar rounds slammed into the Damascus suburb of Jaramana, killing at least seven people and wounding dozens, state media and activists said.

The Britain-based Syrian Observatory for Human Rights said the shells hit near a municipality building and a school in Jaramana. The Observatory, which relies on reports from a network of activists on the ground, said 10 people were killed and 30 were wounded in the attacks.

Syrian state-run SANA news agency said seven people were killed in the attack.

The differences in the death tolls could not be immediately reconciled.

Also Wednesday, Syrian church officials said the whereabouts of two bishops kidnapped in northern Syria remain unknown, a day after telling reporters the priests had been released.

Bishop Tony Yazigi of the Damascus-based Greek Orthodox Church said Tuesday that the bishops, both of whom are based in the northern city of Aleppo, had been released. But later on Tuesday, the Syrian Orthodox Patriarchate in the capital said in a statement on its website that it had not received "any official document indicating the (bishops') release."

Gunmen pulled Bishop Boulos Yazigi of the Greek Orthodox Church and Bishop John Ibrahim of the Assyrian Orthodox Church from their car and killed their driver on Monday while they were traveling outside Aleppo. It was not clear who abducted the priests.

But Bishop Yazigi, who is the brother on one of the abductees, said the gunmen are believed to be Chechen fighters from Jabhat al-Nusra group, one of the most powerful of the myriad of rebel factions fighting in Syria. Yazigi declined to say what made it appear that the Nusra Front was involved.

That account corresponded to one provided by the Observatory, which said foreign fighters had abducted the bishops near a checkpoint outside Aleppo. Observatory director Rami Abdul-Rahman said Wednesday that activists in the area where the kidnapping took place say the gunmen were foreign fighters from the Caucuses.

However, the main opposition group, the Syrian National Coalition, condemned the kidnapping and blamed Assad's regime.

In Rome, Pope Francis called for the rapid release of the two bishops. In his appeal Tuesday, the pontiff called the abduction "a dramatic confirmation of the tragic situation in which the Syrian population and its Christian community is living."

There has been a spike in kidnappings in northern Syria, much of which is controlled by the rebels, and around Damascus in recent months. Residents blame criminal groups that have ties to both the regime and the rebels for the abductions of wealthy residents traveling to Syria from neighboring Turkey and Lebanon.

___

Associated Press writers Bassem Mroue and Ryan Lucas contributed to this report.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/3d281c11a96b4ad082fe88aa0db04305/Article_2013-04-24-Syria/id-3239e7afcfa14ec28d291ef31bab6527

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Wednesday, April 24, 2013

Finance director: Mobile sales taxes on pace to meet expectations ...

MOBILE, Alabama ? The city's sales tax revenues are on pace to meet projections the city's administration pitched last year when pushing for a controversial penny tax increase, the city's finance director told a City Council panel today.

Barbara Malkove, the head of the administration's finance department, said without the penny tax increase, the city's budget would be hit with $11.3 million less in revenues.

According to a report Malkove presented to the council's finance committee, the city has raised $77.7 million in sales taxes right now, which is more than the $66.4 million that would have been raised had the City Council not endorsed the penny tax increase in October.

Malkove said the one-cent increase for six months in 2013, has raised $16.6 million, or more than the $30 million the city projected the tax would generate. Malkove noted that the busiest shopping days of the budget year ? Christmas, New Year's, and Mardi Gras ? are reflected in the $16.6 million figure.

"We are on budget for collecting the sales tax," Malkove said. "Everything we budgeted, we are on track."

Despite Malkove's comments, the city's sales tax revenues from Oct. 1 to March 31, are a lot less than in 2011, and are slumping due to struggles in the national economy.

"If you look at the last time we put the penny (increase) in two to three years ago, we receiving approximately $34 million," Malkove said, referring to the amount that was generated during 12 months of the one-cent increase. "This year, we are only projecting to receive $30 million. Our projections decreased because of the national economy and the local economy for that matter."

Malkove's report painted a rosier picture of the city's biggest revenue source than her update in January, when she said November sales tax figures -- the first month of the city's sales tax -- were struggling. John Sharp, Press Register

Source: http://blog.al.com/live/2013/04/finance_director_mobile_sales.html

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